1879, Johns Hopkins University graduate student Constantin Fahlberg is continuing its synthesis of toluene series derivatives. One day at lunchtime, he found that the bread in his hand was exceptionally sweet, so he analyzed the synthetic series of toluene compounds and finally found saccharin.
This accidental discovery paved the way for Falidberg to new inventions. From then on, he concentrated all his energies on studying the substance extracted from the coal tar. He extracted toluene from black, sticky, smelly coal tar, after sulfuric acid sulfonation, pentachlorophenol and ammonia treatment, then with potassium permanganate oxidation, finally through crystallization, dehydration and get a special sweet white crystals. He called it "saccharin" and measured it $number times sweeter than sucrose.
Falidberg immediately announced his invention and patented it in the United States. In 1886, the chemist relocated to Germany, where he established the world's first plant to distill saccharin from coal tar. Saccharin began to break into people's lives.