The main raw materials for saccharin production are toluene, chloro sulfonic acid, O-toluene amine, etc., are petrochemical products. Toluene volatile and burning, and even cause explosion, a large intake of human body will cause acute poisoning, health hazards to the human body is greater; chlorine sulfonic acid is easy to absorb water decomposition of hydrogen chloride gas, harmful to human body, and easy to explode; the intermediates produced during the production of saccharin are also harmful to human health. Saccharin in the production process will also seriously pollute the environment. In addition, from some small and medium-sized saccharin factory privately into the vast number of small and medium-sized towns, rural market saccharin, but also because of rough process, the process is not complete and other reasons contain heavy metals, ammonia compounds, arsenic and other sundries. They remain and accumulate in the human body for a long term, affecting the health of the human body in varying degrees.